Bacoside-A, a major constituent isolated from Bacopa monniera is held in high repute as a potent nerve tonic. Rats were pretreated with Bacoside A (10mg/kg and 20mg/kg body weight) for 21 days. A Parkinsonian model in rats was developed by giving 6-hydroxy dopamine (12μg/2μl in 0.1% ascorbic acidsaline) in the right striatum on 22 day. A significant protection on lipid peroxidation, glutathione...

Excitatory amino acid (EAA) receptor-mediated events have recently been implicated in dopaminergic mechanisms of neurotoxicity. 2,4,5-Trihydroxyphenylalanine (6-hydroxy-DOPA, TOPA), the ortho-hydroxylated derivative of the dopamine precursor 2,4-dihydroxyphenylalanine (L-DOPA), has recently been reported to have neurotoxic properties which are blocked by CNQX, a specific antagonist of the AMPA ...

Objective(s): The present study was conducted to examine the effect of sleep deprivation (SD) on the anti-apoptotic pathways in Parkinsonian rats. Materials and Methods: Male Wistar rats (n = 40) were assigned to four groups (10 animals each): sham surgery (Sham), 6-hydroxydopamine (6-OHDA)-lesioned (OH), 6-OHDA-lesioned plus grid control (OH+GC), 6-OHDA-lesioned plus SD (OH+SD). Parkinson’s di...

Objective: Menthaaquatica, plant which is showing monoamine oxidase-B (MAO-B) inhibition and antioxidant activity was assessed for anti-Parkinson’s activity in 6-hydroxy dopamine (6-OHDA) lesionedwistar rat model. Materials and Method: Menthaaquaticaethanolextract (EMA) was obtained by using alcoholic solvent. Acute oral toxicity of Menthaaquaticaextract was carried out in wistar rats. Rats wer...

In the present study, R-(-)-apomorphine and three of its analogs were studied for their potency in decreasing the release of dopamine in the striatum after subcutaneous administration and for their oral bioavailability using the microdialysis technique in freely moving rats. The analogs R-(-)-N-n-propylnorapomorphine and R-(-)-11-hydroxy-N-n-propylnoraporphine displayed a higher potency than R-...